Fish oil and glycemic control in diabetes. A meta-analysis
Friedberg CE, Janssen MJ, Heine RJ, Grobbee DE
Diabetes care · 176 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Según 1 financiador declarado.
Publicación
- Publicado
- 1998-04-01 · Diabetes Care · vol. 21 · número 4 · págs. 494–500
- Editorial
- American Diabetes Association
- Citado
- 303 citas · más que el 99% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Diabetes Treatment and Management
- Palabras clave
- fish oil, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, glycemic control, diabetes mellitus, type 1 diabetes, type 2 diabetes, hypertriglyceridemia, serum triglycerides, LDL cholesterol, HbA1c, fasting blood glucose, dyslipidemia, dose-response relationship, dietary supplementation
- MeSH
- humans, diabetes mellitus, diabetes mellitus, type 1, diabetes mellitus, type 2, blood glucose, dietary fats, unsaturated, triglycerides, fish oils, cholesterol, ldl, glycated hemoglobin
4 autores
- Cylla E. Friedberg🇳🇱Vrije Universiteit Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Martien J F M Janssen🇳🇱Rijnland Ziekenhuis
- Robert J. Heine🇳🇱Vrije Universiteit Amsterdam
- Diederick E. Grobbee🇳🇱Utrecht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Hypertriglyceridemia is associated with cardiovascular disease in diabetes. Fibrates effectively lower, but do not always normalize, serum triglyceride levels. Fish oil supplements may then be added to lower serum triglyceride levels. Doubt remains whether the net effect of fish oil intake on glycemic control is beneficial in diabetes. We therefore performed a meta-analysis from published clinical trials.
Research design and methods
Data sources were Medline (Cologne, Germany), Excerpta Medica, Current Contents, review articles, and published reference lists. Publications of 26 trials were selected, and all trials included more than five diabetes (IDDM and NIDDM) patients and addressed the effects of fish oil (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) on serum lipids and glucose tolerance. We (C.E.F., M.J.F.M.J.) extracted data independently based on predetermined criteria. Studies were classified according to design.
Results
All studies combined showed a decrease in mean triglyceride concentrations in association with fish oil: -0.60 mmol/l (95% CI, -0.84 to -0.33, P < 0.01) and a slight but significant increase in serum LDL cholesterol: 0.18 mmol/l (95% CI, 0.04-0.32, P = 0.01), with both findings most prominent in NIDDM. No significant changes in HbA1c percentages occurred in diabetic subjects treated with fish oil. Fasting blood glucose levels were increased with borderline significance in NIDDM subjects (0.43 mmol/l [95% CI, 0.00-0.87], P = 0.06) and were significantly lower in IDDM subjects (-1.86 mmol/l [95% CI, -3.1 to -0.61], P < 0.05). Significant dose-response effects of EPA (g/day) on HbA1c and triglycerides and of DHA (g/day) on fasting blood glucose levels, HbA1c, and triglycerides were demonstrated only in NIDDM subjects.
Conclusions
The use of fish oil has no adverse affects on HbA1c in diabetic subjects and lowers triglyceride levels effectively by almost 30%. However, this may be accompanied by a slight increase in LDL cholesterol concentration. Fish oil may be useful in treating dyslipidemia in diabetes.
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