Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil
Mero N, Syvänne M, Rosseneu M, Labeur C, Hilden H, Taskinen MR
European journal of clinical investigation · 15 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1998-05-01 · Eur J Clin Invest · vol. 28 · número 5 · págs. 407–415
- Editorial
- Wiley
- Citado
- 21 citas · más que el 87% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipid metabolism and disorders · Fatty Acid Research and Health · Lipid metabolism and biosynthesis
- Palabras clave
- oral fat tolerance test, retinyl esters, soybean oil, saturated fat, mixed meal, triglyceride-rich lipoproteins, chylomicrons, VLDL, apolipoprotein B-48, apolipoprotein B-100, apolipoprotein E, HDL cholesterol
- MeSH
- humans, cholesterol, lipids, dietary fats, soybean oil, triglycerides, lipoproteins, apolipoproteins b, apolipoproteins e, retinol-binding proteins, fasting, postprandial period, adult, male, apolipoprotein b-100, apolipoprotein b-48, retinol-binding proteins, plasma, retinyl esters
6 autores
- Mero🇫🇮University of Helsinki
- Syvänne🇫🇮University of Helsinki
- Rosseneu🇧🇪Ghent University
- Labeur🇧🇪Ghent University
- Hilden🇫🇮University of Helsinki
- Marja‐Riitta Taskinen🇫🇮 · autor de correspondenciaUniversity of Helsinki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post-prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests.
Methods
We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid cream meal and a liquid soybean oil meal. The study group consisted of 10 healthy normolipidaemic men. We measured triglycerides (TGs), retinyl esters (REs), apolipoprotein E (apoE), apolipoprotein B-48 (apoB-48) and apolipoprotein B-100 (apoB-100) in plasma and in triglyceride-rich lipoprotein (TRL) fractions separated by density-gradient ultracentrifugation at baseline and 3, 4, 6, and 8 h after the FTTs.
Results
We observed similar TGs, apoE, apoB-48 and apoB-100 responses after all three FTTs, despite the different fatty acid composition of the meals. In contrast, the commonly used marker for exogenous particles, RE, differed clearly when polyunsaturated (soybean oil) and saturated fat (cream or mixed meal) were used. The RE response in plasma (P < 0.005, repeated measures ANOVA), in chylomicrons (P < 0.013) and in very low-density lipoprotein (VLDL) 1 (P < 0.017), as well as the RE area under the incremental curve in plasma and chylomicron fractions, were markedly increased after the soybean oil meal compared with the mixed meal and cream meal tests. The peak of RE response occurred parallel to the responses of other markers (i.e. TG or apoB-48) of post-prandial TRL during soybean oil meal. In contrast, RE peak concentration was delayed after saturated fat-containing meals. After soybean oil, FTT plasma cholesterol concentration was lower and the chylomicron cholesterol concentration was higher compared with mixed or cream meals, but no differences were detected in post-prandial high-density lipoprotein (HDL)-cholesterol concentration.
Conclusion
When the amount of fat is similar, post-prandial responses of TG, apoE, apoB-48, apoB-100 and HDL-cholesterol were comparable after different FTTs.
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