Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans
Grimsgaard S, Bønaa KH, Hansen JB, Myhre ES
The American journal of clinical nutrition · 130 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1998-07-01 · Am J Clin Nutr · vol. 68 · número 1 · págs. 52–59
- Editorial
- Elsevier BV
- Citado
- 201 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular Function and Risk Factors · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, dietary supplementation, blood pressure, heart rate, cardiac mechanics, left ventricular diastolic filling, plasma phospholipid fatty acids, saturated fatty acids, docosapentaenoic acid, marine oils, corn oil
- MeSH
- heart, humans, dietary fats, unsaturated, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, phospholipids, double-blind method, blood pressure, heart rate, ventricular function, left, dietary supplements, adult, middle aged, male, hemodynamics
4 autores
- Sameline Grimsgaard🇳🇴 · autor de correspondenciaUiT The Arctic University of Norway
- Kaare Harald Bønaa🇳🇴UiT The Arctic University of Norway
- John‐Bjarne Hansen🇳🇴UiT The Arctic University of Norway
- Eivind S. P. Myhre🇳🇴UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
The hemodynamic effects of highly purified eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have not been evaluated in humans. We therefore conducted a randomized, double-blind, parallel-design intervention study to assess possible separate effects of EPA and DHA on blood pressure, heart rate, and cardiac mechanics. Healthy, nonsmoking men aged 36-56 y (n = 224) were randomly assigned to dietary supplementation with 4 g/d of ethyl ester concentrates of DHA or EPA or 4 g corn oil/d (control). Mean blood pressure at baseline was 122/77 mm Hg and was positively associated with concentrations of serum phospholipid saturated fatty acids. Blood pressure did not change during the intervention. Mean heart rate at baseline was 63.4 beats/min; it decreased 2.2 beats/min in the DHA group (P = 0.006 compared with control), increased 1.9 beats/min in the EPA group (P = 0.04 compared with control), and remained practically unchanged in the control group. In a pooled analysis, changes in heart rate were independent of baseline heart rate and were associated with changes in concentrations of serum phospholipid DHA and docosapentaenoic acid (22:5n-3). Echocardiography in a subsample of 52 men showed improved left ventricular diastolic filling in the marine oil groups compared with the corn oil group (P = 0.02). In contrast, an increase in plasma concentrations of saturated fatty acids was associated with delayed diastolic filling. We conclude that dietary DHA and EPA influence heart rate and that the fatty acid composition of plasma phospholipids may affect cardiac mechanics in humans.
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