Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants
Birch EE, Hoffman DR, Uauy R, Birch DG, Prestidge C
Pediatric research · 302 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NICHD NIH HHS
- Subvenciones
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-22380)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1998-08-01 · Pediatr Res · vol. 44 · número 2 · págs. 201–209
- Editorial
- Springer Nature
- Citado
- 494 citas · más que el 100% de estudios similares · 36.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Child Nutrition and Water Access
- Palabras clave
- docosahexaenoic acid, arachidonic acid, term infants, infant formula supplementation, visual acuity development, sweep visual evoked potential, preferential looking, breast milk, omega-3 fatty acids, infant growth
- MeSH
- humans, docosahexaenoic acids, fatty acids, unsaturated, arachidonic acid, fatty acids, essential, diet, breast feeding, evoked potentials, visual, visual acuity, infant, infant, newborn, female, male, infant nutritional physiological phenomena
5 autores
- Eileen E. Birch🇺🇸Retina Foundation of the Southwest
- Dennis R. Hoffman🇺🇸The University of Texas Southwestern Medical Center
- Ricardo D. Uauy🇺🇸🇨🇱Retina Foundation of the Southwest; University of Chile; The University of Texas Southwestern Medical Center
- David G. Birch🇺🇸Retina Foundation of the Southwest; The University of Texas Southwestern Medical Center
- Claude B. Prestidge🇨🇱🇺🇸University of Chile; The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
The need for a dietary supply of docosahexaenoic acid (DHA) and arachidonic aid (AA) in term infants was evaluated in a double-masked randomized clinical trial of the effects of supplementation of term infant formula with DHA (0.35% of total fatty acids) or with DHA (0.36%) and AA (0.72%) on visual acuity development. One hundred and eight healthy term infants were enrolled in the study; 79 were exclusively formula-fed from birth (randomized group) and 29 were exclusively breast-fed (gold standard group). Infants were evaluated at four time points during the first 12 mo of life for blood fatty acid composition, growth, sweep visual evoked potential (VEP) acuity, and forced choice preferential looking acuity. Supplementation of term infant formula with DHA or with DHA and AA during the first 4 mo of life yields clear differences in total red blood cell (RBC) lipid composition. Supplementation of term infant formula with DHA or with DHA and AA also yields better sweep VEP acuity at 6, 17, and 52 wk of age but not at 26 wk of age, when acuity development reaches a plateau. The RBC lipid composition and sweep VEP acuity of supplemented infants was similar to that of human milk-fed infants, whereas the RBC lipid composition and sweep VEP acuity of unsupplemented infants was significantly different from human milk-fed infants. Differences in acuity among diet groups were too subtle to be detected by the forced choice preferential looking protocol. Infants in all diet groups had similar rates of growth and tolerated all diets well. Thus, early dietary intake of preformed DHA and AA appears necessary for optimal development of the brain and eye of the human infant.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.