Hypothalamic-pituitary-adrenocortical responses to psychological stress and caffeine in men at high and low risk for hypertension
al'Absi M, Lovallo WR, McKey B, Sung BH, Whitsett TL, Wilson MF
Psychosomatic medicine · 69 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL32050)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1998-01-01 · Psychosom Med · vol. 60 · número 4 · págs. 521–527
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 98 citas · más que el 73% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Stress Responses and Cortisol · Coffee research and impacts · Blood Pressure and Hypertension Studies
- Palabras clave
- hypothalamic-pituitary-adrenal axis, caffeine, psychological stress, hypertension risk, ACTH, cortisol, men, dietary caffeine
- MeSH
- pituitary-adrenal system, hypothalamo-hypophyseal system, humans, hypertension, genetic predisposition to disease, caffeine, hydrocortisone, risk factors, cross-over studies, double-blind method, stress, psychological, arousal, blood pressure, adult, male, adrenocorticotropic hormone
6 autores
- Mustafa Al’Absi🇺🇸University of Minnesota; United States Department of Veterans Affairs; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
- William R. Lovallo🇺🇸United States Department of Veterans Affairs; University of Oklahoma Health Sciences Center
- Barbara S. McKey🇺🇸United States Department of Veterans Affairs; University of Oklahoma Health Sciences Center
- Bong Hee Sung🇺🇸United States Department of Veterans Affairs; University of Oklahoma Health Sciences Center
- Thomas L. Whitsett🇺🇸United States Department of Veterans Affairs; University of Oklahoma Health Sciences Center
- Michael F. Wilson🇺🇸United States Department of Veterans Affairs; University of Oklahoma Health Sciences Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used.
Method
Adrenocorticotropic hormone (ACTH) and cortisol levels in plasma were assessed at rest and in response to 60-minutes of continuous work on a mental stressor (arithmetic) and a psychomotor task (reaction time) on four test sessions held on separate days.
Results
Tasks alone caused greater ACTH and cortisol increases in high risk men than in the low risk group. Caffeine alone elevated ACTH and cortisol in both groups, with more immediate responses in the high risk group. Both groups showed significant ACTH and cortisol responses to caffeine plus tasks, with the high risk group showing more persistent elevations. The high risk group also showed the highest levels of ACTH and cortisol after caffeine plus tasks.
Conclusions
These findings demonstrate for the first time the combined effects of caffeine plus stress on ACTH and demonstrate greater corticosteroid effects in hypertension-prone men. As such, they may have implications for the dietary use of caffeine during periods of stress and in those at risk for hypertension.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.