Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly
Chel VG, Ooms ME, Popp-Snijders C, Pavel S, Schothorst AA, Meulemans CC, Lips P
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 113 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1998-08-01 · J Bone Miner Res · vol. 13 · número 8 · págs. 1238–1242
- Editorial
- Oxford University Press
- Citado
- 205 citas · más que el 89% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 18 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Palabras clave
- UVB irradiation, vitamin D deficiency, secondary hyperparathyroidism, parathyroid hormone, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, vitamin D3 supplementation, elderly nursing home residents, psychogeriatric patients, serum calcium, minimal erythema dose
- MeSH
- humans, vitamin d deficiency, hyperparathyroidism, secondary, calcium, cholecalciferol, parathyroid hormone, vitamin d, administration, oral, ultraviolet rays, aged, aged, 80 and over, nursing homes, netherlands, female
7 autores
- Victor G. M. Chel
- Marius Ooms🇳🇱Vrije Universiteit Amsterdam
- C. Popp‐Snijders🇳🇱Vrije Universiteit Amsterdam
- S Pavel🇳🇱Leiden University; Leiden University Medical Center
- Albert A. Schothorst🇳🇱Leiden University; Leiden University Medical Center
- C. C. E. Meulemans
- Paul T.A.M. Lips🇳🇱 · autor de correspondenciaVrije Universiteit Amsterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
The objective of this study was to compare the effect of ultraviolet radiation (UV) and oral vitamin D3 on the vitamin D status and parathyroid hormone (PTH) concentration in elderly nursing home patients. The design of the study was a randomized clinical trial. The setting was a psychogeriatric nursing home. Subjects included 45 female psychogeriatric patients with a mean age of 85 years. Exclusion criteria were going outdoors more than once a week and the presence of actinic or cancer skin lesions. Intervention was random allocation of UV-B irradiation at half the minimal erythemal dose of the lower back, three times per week during 12 weeks (UV-B), or oral vitamin D3 400 IU/day during 12 weeks (VIT-D), or no treatment (CONTR). Main outcome measures were change in fasting serum levels of vitamin D metabolites at 0, 2, 4, 8, and 12 weeks in the treatment groups, compared with the control group. PTH(1-84) was measured at 0 and 12 weeks. Baseline serum 25-hydroxyvitamin D (25(OH)D) was lower than 30 nmol/l in 95% of the participants. It increased to a median value of around 60 nmol/l after 12 weeks both in the UV-B and VIT-D groups, whereas there was no change in the CONTR group. Serum 1,25-dihydroxyvitamin D increased significantly in the UV-B group. Serum calcium increased significantly in both treatment groups. Serum PTH decreased more than 30% in both treatment groups (p < 0.001), whereas there was no significant change in the control group. Irradiation with UV-B in the very elderly for a few minutes per day leads to adequate improvement of the vitamin D status. It is as effective as oral vitamin D3 in increasing serum 25(OH)D and suppressing secondary hyperparathyroidism.
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