Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressures
Kawano Y, Matsuoka H, Takishita S, Omae T
Hypertension (Dallas, Tex. : 1979) · 94 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Fondation pour la Recherche Médicale
Según 1 financiador declarado.
Publicación
- Publicado
- 1998-08-01 · Hypertension · vol. 32 · número 2 · págs. 260–265
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 156 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Palabras clave
- magnesium supplementation, essential hypertension, blood pressure reduction, magnesium oxide, serum magnesium, urinary magnesium excretion, ambulatory blood pressure, home blood pressure monitoring, lifestyle modification
- MeSH
- humans, hypertension, magnesium, blood pressure monitoring, ambulatory, cross-over studies, blood pressure, adult, aged, middle aged, female, male
4 autores
- Yuhei Kawano🇯🇵National Cerebral and Cardiovascular Center
- Hiroaki Matsuoka🇯🇵National Cerebral and Cardiovascular Center
- Shuichi Takishita🇯🇵National Cerebral and Cardiovascular Center
- Teruo Omae🇯🇵National Cerebral and Cardiovascular Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
An increase in magnesium intake has been suggested to lower blood pressure (BP). However, the results of clinical studies are inconsistent. We studied the effects of magnesium supplementation on office, home, and ambulatory BPs in patients with essential hypertension. Sixty untreated or treated patients (34 men and 26 women, aged 33 to 74 years) with office BP >140/90 mm Hg were assigned to an 8-week magnesium supplementation period or an 8-week control period in a randomized crossover design. The subjects were given 20 mmol/d magnesium in the form of magnesium oxide during the intervention period. In the control period, office, home, and average 24-hour BPs (mean+/-SE) were 148.6+/-1.6/90.0+/-0.9, 136.4+/-1.3/86.8+/-0.9, and 133.7+/-1.3/81.0+/-0.8 mmHg, respectively. All of these BPs were significantly lower in the magnesium supplementation period than in the control period, although the differences were small (office, 3.7+/-1.3/1.7+/-0.7 mmHg; home, 2.0+/-0.8/1.4+/-0.6 mmHg; 24-hour, 2.5+/-1.0/1.4+/-0.6 mm Hg). Serum concentration and urinary excretion of magnesium increased significantly with magnesium supplementation. Changes in 24-hour systolic and diastolic BPs were correlated negatively with baseline BP or changes in serum magnesium concentration. These results indicate that magnesium supplementation lowers BP in hypertensive subjects and this effect is greater in subjects with higher BP. Our study supports the usefulness of increasing magnesium intake as a lifestyle modification in the management of hypertension, although its antihypertensive effect may be small.
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