Physical dependence increases the relative reinforcing effects of caffeine versus placebo
Garrett BE, Griffiths RR
Psychopharmacology · 38 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (R01 DA03890)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1998-09-09 · Psychopharmacology (Berl) · vol. 139 · número 3 · págs. 195–202
- Editorial
- Springer Science+Business Media
- Citado
- 69 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Neurotransmitter Receptor Influence on Behavior · Substance Abuse Treatment and Outcomes
- Palabras clave
- caffeine, physical dependence, drug reinforcement, withdrawal symptoms, willingness to pay, caffeine withdrawal
- MeSH
- saliva, humans, substance-related disorders, substance withdrawal syndrome, caffeine, central nervous system stimulants, self administration, analysis of variance, cross-over studies, double-blind method, reward, adult, middle aged, female, male, surveys and questionnaires, reinforcement, psychology
2 autores
- Bridgette E. Garrett🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Roland R. Griffiths🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Using a within-subject cross-over design, this study examined the role of physical dependence in caffeine reinforcement by experimentally manipulating physical dependence. Each subject was exposed to two chronic drug phases (300 mg/70 kg/day caffeine and placebo) for 9-12 days, with order of phases counterbalanced across subjects. On 2 separate days immediately following each of the chronic drug exposures, subjects received acute doses of either caffeine (300 mg/70 kg) or placebo in counterbalanced order. The reinforcing effects of these drugs were then determined by using a multiple-choice procedure in which subjects made a series of discrete choices between receiving varying amounts of money or receiving the drug again, and a choice between the two drugs. To ensure that subjects completed the form carefully, following exposure to both of the acute drug administrations, one of the subject's previous choices from the multiple-choice form was randomly selected and the consequence of that choice was implemented. When subjects were maintained on chronic caffeine, they were willing to forfeit significantly more money and showed significant increases in typical withdrawal symptoms (e.g. fatigue, mood disturbance) after receiving placebo as compared to the other three conditions. When subjects were maintained on chronic caffeine, they also chose to receive caffeine over placebo twice as often than when they were maintained on chronic placebo. These findings provide the strongest evidence to date indicating that caffeine physical dependence increases the relative reinforcing effects of caffeine versus placebo.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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