Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity
Clapper ML, Szarka CE, Pfeiffer GR, Graham TA, Balshem AM, Litwin S, Goosenberg EB, Frucht H, Engstrom PF
Clinical cancer research : an official journal of the American Association for Cancer Research · 23 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- NCI NIH HHS
Según 1 financiador declarado.
Publicación
- Publicado
- 1997-01-01 · Clin Cancer Res · vol. 3 · número 1 · págs. 25–30
- Editorial
- National Institutes of Health
- Citado
- 45 citas · más que el 61% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Glutathione Transferases and Polymorphisms · Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities
- Palabras clave
- broccoli, cruciferous vegetables, glutathione S-transferase, dietary supplements, chemoprevention, colorectal cancer, colonic mucosa, detoxification enzymes
- MeSH
- gastric mucosa, lymphocytes, animals, mice, inbred icr, humans, mice, brassica, colorectal neoplasms, glutathione transferase, chemoprevention, risk factors, enzyme induction, dietary supplements, adult, aged, middle aged, female, male
9 autores
- Margie L. Clapper🇺🇸Fox Chase Cancer Center
- Christine E. Szarka
- Gordon R. Pfeiffer
- Todd A. Graham
- Andrew M. Balshem
- Samuel Litwin
- Eric B. Goosenberg
- Harold Frucht
- Paul F. Engstrom
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies suggest that cruciferous vegetables may provide protection against carcinogen exposure by inducing detoxification enzymes. ICR(Ha) mice were gavaged with broccoli tablets (1 g/kg), and colon tissues were collected after treatment. Glutathione S-transferase (GST) activity was assayed and peaked on days 1 and 2 after treatment, respectively (P = 0.03). Elevations in GST activity were attributed to the increased expression of mu and pi. These data supported a clinical assessment of broccoli supplements. Twenty-nine subjects at increased risk for colorectal cancer were randomized to group 1 (no cruciferous vegetables) or group 2 (broccoli supplements, 3 g/day) for 14 days. Blood samples and colon biopsies were obtained pre- and postintervention. No significant difference was observed between the GST activities of the control and broccoli supplementation groups posttreatment. Mean lymphocyte GST activity was 107% of baseline in the broccoli supplementation group (range, 79-158%) and 102% of baseline in the control group (range, 75-158 percent;). Correlation of the GST activities of blood lymphocytes and colon mucosa taken simultaneously suggested that the GST activity of blood lymphocytes may be used as a biomarker of the responsiveness of colon tissue to chemopreventive regimens. Future clinical studies evaluating cruciferous vegetables should consider using concentrated dietary supplements in subjects with a previous history of colorectal cancer.
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