Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men
Pang D, Allman-Farinelli MA, Wong T, Barnes R, Kingham KM
The British journal of nutrition · 31 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Medical Research Council
- Gobierno
- National Medical Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 1998-08-01 · Br J Nutr · vol. 80 · número 2 · págs. 163–7
- Editorial
- National Institutes of Health
- Citado
- 46 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and biosynthesis · Nutritional Studies and Diet
- Palabras clave
- linoleic acid, alpha-linolenic acid, plasma lipids, cholesterol, HDL cholesterol, LDL cholesterol, HDL subfractions, triglycerides, lipid metabolism, cardioprotection
- MeSH
- humans, cholesterol, lipids, alpha-linolenic acid, safflower oil, linseed oil, linoleic acids, triglycerides, diet, adolescent, adult, male, cholesterol, ldl, cholesterol, hdl
5 autores
- Dona Pang🇦🇺The University of Sydney
- Margaret A Allman-Farinelli🇦🇺The University of Sydney
- T Wong🇦🇺The University of Sydney
- R Barnes🇦🇺The University of Sydney
- Karen Kingham🇦🇺The University of Sydney
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effect of partial dietary replacement of linoleic acid (18:2n-6; linoleic acid-rich diet) with alpha-linolenic acid (18:3n-3; alpha-linolenic acid-rich diet) on plasma lipids was investigated in twenty-nine healthy young men. After a 2-week stabilization period subjects were randomly assigned to either the alpha-linolenic acid-rich diet group (n 15), receiving a mean of 10.1 g of alpha-linolenic acid and 12.1 g of linoleic acid/d, or the linoleic acid-rich diet group (n 14), receiving a mean of 1.0 g of alpha-linolenic acid and 21.0 g of linoleic acid/d, for a 6-week test period. Blood samples were taken at the commencement of the stabilization period and at the start (week 0), midpoint (week 3) and endpoint (week 6) of the test period and plasma lipids analysed. The changes occurring on the linoleic acid-rich diet and alpha-linolenic acid-rich diet were compared but no significant differences in the changes in plasma total cholesterol, LDL-cholesterol, HDL-cholesterol, the subfractions HDL2 and HDL3 or triacylglycerols were found. These results indicate that dietary replacement of linoleic acid with alpha-linolenic acid in the diet of healthy male subjects offers similar cardioprotective benefits with respect to lipid metabolism.
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