U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans
Sehayek E, Nath C, Heinemann T, McGee M, Seidman CE, Samuel P, Breslow JL
Journal of lipid research · 47 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01-RR000102); National Heart, Lung, and Blood Institute (HL-32435-14)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1998-12-01 · J Lipid Res · vol. 39 · número 12 · págs. 2415–2422
- Editorial
- Elsevier BV
- Citado
- 87 citas · más que el 96% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health · Nutrition, Genetics, and Disease
- Palabras clave
- dietary cholesterol absorption, LDL cholesterol, HDL cholesterol, dietary fat, interindividual variability, U-shaped relationship, low-fat low-cholesterol diet, high-fat high-cholesterol diet
- MeSH
- humans, cholesterol, dietary, lipoproteins, regression analysis, cross-over studies, intestinal absorption, reference values, adult, middle aged, female, male
7 autores
- Ephraim Sehayek🇺🇸Rockefeller University
- Chithranjan Nath🇺🇸Rockefeller University
- Thomas Heinemann🇩🇪University of Bonn
- Monnie McGee🇺🇸Rockefeller University
- Cynthia E. Seidman🇺🇸Rockefeller University
- Paul Samuel🇺🇸Rockefeller University
- Jan L. Breslow🇺🇸 · autor de correspondenciaRockefeller University
Resumen
El texto original del estudio, en el idioma en que se publicó.
A possible relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness was examined in 18 normal subjects fed low fat low cholesterol, high fat low cholesterol, and high fat high cholesterol diets. For the group, neither dietary cholesterol nor dietary fat affected the percentage dietary cholesterol absorption, whereas dietary cholesterol intake raised total and LDL-C and dietary fat raised total, LDL, and HDL-C. On a fixed diet there was approximately a 2-fold variation among subjects in percentage dietary cholesterol absorption. Subjects also varied in response to dietary cholesterol and fat with regard to dietary cholesterol absorption and plasma lipoprotein responsiveness. There was a U-shaped parabolic relationship between dietary cholesterol-induced percent change in LDL-C and the change in percentage dietary cholesterol absorption (R2 = 0.62, P = 0.005). A similar but weaker relationship characterized the responsiveness of HDL-C (R2 = 0.38, P = 0.05). For the group, increased cholesterol intake raised dietary cholesterol mass absorption from 1.6 to 4.6 mg/kg per day, but the range of increase was from 1 to 4.7 mg/kg per day. Increased fat intake also affected dietary cholesterol mass absorption with most subjects displaying a strong inverse relationship between fat intake and mass absorption (r = -0.77, P < 0.003). In summary: i) the percentage change in dietary cholesterol absorption in response to dietary cholesterol does appear to regulate diet responsiveness of LDL and HDL-C, and ii) the large variability in percent absorption and changes in percentage and mass absorption in response to dietary cholesterol suggest the presence of genetically determined differences among individuals in the regulation of dietary cholesterol absorption.
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